Article
Pathogen-focused metagenomic analysis reveals predominance of human rotavirus genotypes G3 and G12 in Zambian pediatric diarrhea cases.
Scientific reports - 25 Nov 2025
Mwape Innocent, Silwamba Suwilanji, Chibesa Kennedy, Luchen Charlie C, Musukuma-Chifulo Kalo, Collins John, Chauwa Adriace, Liswaniso Fraser, Nzangwa Tamara B, Kuntawala Dhvani H, Chisenga Caroline C, De Beer Corena, Chilengi Roma, Lu X J, Yingst Sam, Wickiser J Kenneth, Simuyandi Michelo
Abstract excerpt
Despite global improvements in water, sanitation, and rotavirus vaccination, rotavirus-associated diarrhea continues to cause significant morbidity and mortality among children in low-to-middle-income countries. Genomic surveillance is essential for evaluating vaccine efficacy and detecting emerging escape variants. In this study, we used VirCapSeq-VERT (VCS) to analyze rotavirus genetic diversity during Zambia's...
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