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Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique.

Scientific reports - 28 Dec 2024

Manjate Filomena, João Eva D, Mwangi Peter, Chirinda Percina, Mogotsi Milton, Garrine Marcelino, Messa Augusto, Vubil Delfino, Nobela Nélio, Kotloff Karen, Nataro James P, Nhampossa Tacilta, Acácio Sozinho, Weldegebriel Goitom, Tate Jacqueline E, Parashar Umesh, Mwenda Jason M, Alonso Pedro L, Cunha Celso, Nyaga Martin, Mandomando Inácio

Abstract excerpt

Post rotavirus vaccine introduction in Mozambique (September 2015), we documented a decline in rotavirus-associated diarrhoea and genotypes changes in our diarrhoeal surveillance spanning 2008-2021. This study aimed to perform whole-genome sequencing of rotavirus strains from 2009 to 2012 (pre-vaccine) and 2017-2018 (post-vaccine). Rotavirus strains previously detected by conventional PCR as G2P[4], G2P[6],...

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Diarrhea
Mozambique
Rotavirus
Rotavirus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rotavirus Vaccines

Toxins, Biological

Viral Nonstructural Proteins

Whole Genome Sequencing

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Identifiers

PMID: 39730435
DOI: 10.1038/s41598-024-79767-4
PMCID: PMC11680989

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