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Article

Novel SOS1 Mutations Associated With Hereditary Gingival Fibromatosis and Dual-Gated Model for SOS1 Activation.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Mar 2026

Gao Qian, Yang Chengcan, Xu Nuo, Song Xiaona, Bian Zhuan, Yang Kai

Abstract excerpt

BACKGROUND: Hereditary gingival fibromatosis (HGF) is a rare, genetically heterogeneous disorder characterized by benign, slowly progressive fibrous overgrowth of the gingiva. This study aimed to identify the pathogenic genes responsible for non-syndromic HGF and to elucidate the activation mechanism for truncated SOS1 protein. METHODS: Genomic DNA was extracted from peripheral blood samples of two unrelated Han...

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Identifiers

PMID: 41290531
DOI: 10.1111/jop.70080

Genes

SOS1
HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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