Article
A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1.
American journal of human genetics - 1 Apr 2002
Hart Thomas C, Zhang Yingze, Gorry Michael C, Hart P Suzanne, Cooper Margaret, Marazita Mary L, Marks Jared M, Cortelli Jose R, Pallos Debora
Abstract excerpt
Hereditary gingival fibromatosis (HGF) is a rare, autosomal dominant form of gingival overgrowth. Affected individuals have a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa. Genetic loci for autosomal dominant forms of HGF have been localized to chromosome 2p21-p22 (HGF1) and chromosome 5q13-q22 (HGF2). To identify the gene responsible for HGF1, we extended genetic...
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