Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NF1 Mutated Gastrointestinal Stromal Tumors With Coamplification of MDM2 and MYC.

Genes, chromosomes & cancer - 1 Nov 2025

Chen Xinyang, Lu Yang, He Xin, He Du, Chen Min, Zhang Hongying

Abstract excerpt

We report a unique case of a 57-year-old man with a gastrointestinal stromal tumor (GIST) that developed a high-grade phenotype and additional genetic alterations in the subsequent recurrence. Histologically, the initial resected tumor showed a typical morphology with uniform spindle-shaped cells arranged in fascicular and whorling patterns. However, based on large tumor size and mitotic activity it was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal Neoplasms
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF1 gene

Share to Mutation

Share to Neoplasm Proteins

Share to Neurofibromin 1

Share to Proto-Oncogene Proteins c-mdm2

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 41288319
DOI: 10.1002/gcc.70096

Genes

MDM2
NF1
KIT
MYC
PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NF1 Mutated Gastrointestinal Stromal Tumors With Coamplification of MDM2 and MYC.PMID 41288319Read ↗

Molecular and clinicopathological features of KIT/PDGFRA wild-type gastrointestinal stromal tumors.Semantic proximity Read ↗

NF1-Associated Gastrointestinal Stromal Tumors Have Unique Clinical, Phenotypic, and Genotypic CharacteristicsSemantic proximity Read ↗

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patientsSemantic proximity Read ↗

Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST caseSemantic proximity Read ↗

Jejunal gastrointestinal stromal tumor that developed in a patient with neurofibromatosis type 1: a case reportSemantic proximity Read ↗

Patient with high-risk GIST not associated with c-KIT mutations: same benefit from adjuvant therapy?Semantic proximity Read ↗

Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.Semantic proximity Read ↗

Plexiform Fibromyxoma with MALAT1–GLI1 Fusion with Limited Myxoid Stroma, Aberrant KIT Expression, and Diffuse D2-40 Expression: A Case ReportSemantic proximity Read ↗

GISTs with NTRK Gene Fusions: A Clinicopathological, Immunophenotypic, and Molecular StudySemantic proximity Read ↗

Primary central nervous system histiocytic sarcoma with somatic NF2 mutation: Case report and review of literature.Semantic proximity Read ↗

Gastrointestinal Stromal Tumor With Multiple Primary Tyrosine Kinase Mutations-Clinicopathologic and Molecular Characterization.Semantic proximity Read ↗

Quadruple-Negative GIST Is a Sentinel for Unrecognized Neurofibromatosis Type 1 Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.