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Article

Cannabinoids shift the basal ganglia microRNA m6A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaques.

Communications biology - 24 Nov 2025

Okeoma Chioma M, Premadasa Lakmini S, Tan Chen S, Ghiran Ionita C, Mohan Mahesh

Abstract excerpt

Epitranscriptomic modifications [N6-methyladenosine (m6A)] regulate various diseases, including cancer and inflammation. Despite their functional relevance in neural development and differentiation, the role of m6A modifications in HIV neuropathogenesis is unknown. Using anti-N6-methyladenosine (m6A) antibody-immunoprecipitation and microarray profiling, we identified m6A modifications in miRNAs in basal ganglia...

Read the complete abstract on PubMed

Topics

Animals
MicroRNAs
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome
Basal Ganglia
Simian Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cannabinoids

Methylation

Adenosine

Anti-Inflammatory Agents

Phenotype

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 41286161
DOI: 10.1038/s42003-025-09049-w
PMCID: PMC12644866

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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