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Inhibition of respiration prompts commitment to unisexual reproduction in Cryptococcus deneoformans.

Cell reports - 23 Dec 2025

Yao Xiaoxia, Tian Xiuyun, Liu Huimin, He Guang-Jun, Chen Lei, Shen Lan, Teng Jinying, Chen Xuanye, Hussein Mohamed, Gherbawy Youssuf, Wang Linqi, Lin Xiaorong, Hu Pengjie

Abstract excerpt

In the human fungal pathogen Cryptococcus deneoformans, sexual reproduction facilitates evolution and adaptation. This fungus can undergo two sexual modes: α × a sexual reproduction and unisexual reproduction (without mating partner cooperation), with α-unisexual reproduction predominating. However, the mechanism driving commitment to α-unisexual reproduction has remained elusive. Here, through a multilayered...

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PMID: 41275490
DOI: 10.1016/j.celrep.2025.116603

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