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Article

Unisexual reproduction in the global human fungal pathogen Cryptococcus neoformans.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2025

Sun Sheng, Bian Zhuyun, Xu Ziyan, Choi Yeseul, Heitman Joseph

Abstract excerpt

The human fungal pathogen Cryptococcus species complex (encompassing Cryptococcus neoformans, Cryptococcus deneoformans, and the Cryptococcus gattii species complexes) exhibits diversity in sexual reproduction, including α-a mating, pseudosexual reproduction, as well as unisexual reproduction initiated from a single isolate or between isolates of the same mating type. A central conundrum is that while most...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41086205
DOI: 10.1073/pnas.2521779122
PMCID: PMC12557769

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