Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans.

mBio - 9 Apr 2025

Bian Zhuyun, Xu Ziyan, Peer Anushka, Choi Yeseul, Priest Shelby J, Akritidou Konstantina, Dasgupta Ananya, Dahlmann Tim A, Kück Ulrich, Nowrousian Minou, Sachs Matthew S, Sun Sheng, Heitman Joseph

Abstract excerpt

Fungal sexual reproduction is controlled by the mating-type (MAT) locus. In contrast to a majority of species in the phylum Basidiomycota that have tetrapolar mating-type systems, the opportunistic human pathogen Cryptococcus neoformans employs a bipolar mating-type system, with two mating types (a and α) determined by a single MAT locus that is unusually large (~120 kb) and contains more than 20 genes. While...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryptococcosis
Share to Cryptococcus neoformans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Genes, Essential

Share to Genes, Mating Type, Fungal

Share to Spores, Fungal

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 39998264
DOI: 10.1128/mbio.00223-25
PMCID: PMC11980393

Genes

RPL22
RPL39

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans.PMID 39998264Read ↗

Essential genes encoded by the mating-type locus of the human fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic FungiSemantic proximity Read ↗

Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans.Semantic proximity Read ↗

Essential Gene Discovery in the Basidiomycete Cryptococcus neoformans for Antifungal Drug Target PrioritizationSemantic proximity Read ↗

Phenotypic characterization of <i>HAM1</i> , a novel mating regulator of the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Dissecting the homeodomain <i>MAT</i> locus and engineering novel tripolar and bipolar mating systems in <i>Cryptococcus amylolentus</i>Semantic proximity Read ↗

Phenotypic characterization of HAM1, a novel mating regulator of the fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes.Semantic proximity Read ↗

Evolution of the Mating Type Locus: Insights Gained from the Dimorphic Primary Fungal Pathogens Histoplasma capsulatum , Coccidioides immitis , and Coccidioides posadasiiSemantic proximity Read ↗

Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species ComplexSemantic proximity Read ↗

Organization and Evolutionary Trajectory of the Mating Type (MAT) Locus in Dermatophyte and Dimorphic Fungal PathogensSemantic proximity Read ↗

Transcription Factors Mat2 and Znf2 Operate Cellular Circuits Orchestrating Opposite- and Same-Sex Mating in Cryptococcus neoformansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.