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Article

Unisexual reproduction reverses Muller's ratchet.

Genetics - 1 Nov 2014

Roach Kevin C, Heitman Joseph

Abstract excerpt

Cryptococcus neoformans is a pathogenic basidiomycetous fungus that engages in outcrossing, inbreeding, and selfing forms of unisexual reproduction as well as canonical sexual reproduction between opposite mating types. Long thought to be clonal, >99% of sampled environmental and clinical isolates of C. neoformans are MATα, limiting the frequency of opposite mating-type sexual reproduction. Sexual reproduction...

Topics

Animals
Cryptococcosis
Cryptococcus neoformans
Disease Models, Animal
Genetic Fitness
Genetic Loci
Mice
Mutation
Reproduction, Asexual
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25217049
DOI: 10.1534/genetics.114.170472
PMCID: PMC4224152

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