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Genetic variants in VEGF gene family enhance colorectal cancer susceptibility via modulating metabolic pathways.

Archives of toxicology - 1 Mar 2026

Zhou Yutao, Ding Zhutao, Chen Yichu, Gong Qian, Liu Bingxin, Shao Yu, Chen Silu, Wang Meilin, Gu Dongying, Xin Junyi

Abstract excerpt

The genes belonging to vascular endothelial growth factor (VEGF) family played critical roles in tumor angiogenesis and the activation of signaling pathways associated with cancer promotion. However, it remains unclear whether genetic variants within VEGF gene family could influence the development of colorectal cancer. Here, we utilized the genotyping data from 1150 colorectal cancer patients and 1342 healthy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41272180
DOI: 10.1007/s00204-025-04237-3

Genes

VEGFA

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