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Article

Loss of PDR3 alters metabolome in response to MCHM, a synthetic hydrotrope.

Current genetics - 19 Nov 2025

Momtareen Taizina, Ayers Michael C, Patriarcheas Dionysios, McCarthy Liam, Judge Daniel, Poziviak Seth, Leombruno Griffen, Quinn Makaela, Wonsettler Natalie, Lowery Camryn, McCulloch Sarah, Dale Nathan, Jonas Felix, Gallagher Jennifer E G

Abstract excerpt

4-methylcyclohexane methanol (MCHM), an alicyclic alcohol, is a synthetic hydrotrope that induces a starvation response by upregulation of biosynthetic pathways despite the availability of nutrients. To investigate how Saccharomyces cerevisiae adapts its metabolism to tolerate MCHM, we evolved MCHM-resistant strains in In-Lab Evolutions (ILEs). We sequenced the parental (YJM789) with long read sequencing and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41258520
DOI: 10.1007/s00294-025-01333-w
PMCID: PMC13332541

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