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Article

Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder.

European child & adolescent psychiatry - 1 Apr 2026

Li Qian, Qin Kun, Lei Du, Li Wenbin, Tallman Maxwell J, Patino L Rodrigo, Sweeney John A, Gong Qiyong, Li Fei, DelBello Melissa P, McNamara Robert K

Abstract excerpt

Although youth with attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are at increased risk for developing BD, the underlying neurobiological mechanisms remain poorly understood. Aberrant ventrolateral prefrontal cortex (VLPFC) and amygdala (AMY) functional connectivity (FC) have been implicated in the pathophysiology of BD. This study compared VLPFC-AMY FC in...

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PMID: 41251713
DOI: 10.1007/s00787-025-02926-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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