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Article

Identification of alternative splicing events in cows with A1A1 and A2A2 β-casein genotypes using large gap read mapping.

BMC genomics - 17 Nov 2025

Jiménez-Montenegro Lucía, Urrutia Olaia, Cánovas Ángela

Abstract excerpt

BACKGROUND: The A2 β-casein milk variant has gained interest due to potential health benefits, which has contributed to the rise of A2A2 genotypes within dairy herds. Although the A1 to A2 amino acid substitution in β-casein does not directly regulate gene expression, selective breeding for the A2A2 genotype may have indirect transcriptomic consequences in the mammary gland. RESULTS: In this study, we...

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Alternative Splicing
Caseins
Cattle
Glycolipids
Glycoproteins
Lipid Droplets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Isoforms

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PMID: 41249943
DOI: 10.1186/s12864-025-12265-7
PMCID: PMC12625517

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