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Genetic and virulence factors behind the success of high-risk Pseudomonas aeruginosa clones: insights from comparative genomics and an experimental infection model

31 Oct 2025

Abstract excerpt

Introduction Pseudomonas aeruginosa causes severe healthcare-associated infections. High-risk clones are defined by global dissemination and multidrug resistance, yet virulence is heterogeneous. We sought to map accessory-genome determinants associated with high-risk clones by integrating whole-genome sequencing (WGS) with a Caenorhabditis elegans infection model. Methods We analyzed 84 clinical isolates plus...

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PMID: 41244690
DOI: 10.3389/fmicb.2025.1674635

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