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Article

From eyes to brain: A genetic and imaging exploration of thyroid eye disease neurological effects.

Journal of neuroendocrinology - 1 Jan 2026

Yao Jiaqi, Lu Xinjian, Ma Jingxu, Liu Ying, Hao Lu, Liu Jun

Abstract excerpt

Observational studies have reported that thyroid eye disease (TED) may cause structural and functional disorders in the brain, However, it remains uncertain whether this relationship is causal. Genetic data were obtained from the Finn Gen R11 database, yielding 587 imaging-derived phenotypes (IDPs). Single-nucleotide polymorphisms associated with TED were selected as instrumental variables, and multi-variable...

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PMID: 41243140
DOI: 10.1111/jne.70109

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