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Article

A Distinct Subtype of Uterine Sarcoma: Case Report of a High-Grade Uterine Sarcoma With Myogenic Differentiation Harboring a PDGFRB Hotspot Mutation.

International journal of surgical pathology - 1 May 2026

Rivera Glorimar, Huang Laura, Chen Hao

Abstract excerpt

Background: High-grade sarcomas harboring PDGFRB hotspot mutations with myogenic differentiation represent a recently characterized and aggressive subset of uterine sarcomas. First described by Dermawan et al, these tumors exhibit distinct morphological, immunophenotypic, and molecular profiles that differentiate them from conventional leiomyosarcomas. To date, only 13 gynecological tumors with this genetic...

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Source

Identifiers

PMID: 41236896
DOI: 10.1177/10668969251384989

Genes

PDGFRB
ALK
MED12
MYOD1
NOTCH3
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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