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Article

High-Grade Sarcomas with Myogenic Differentiation Harboring Hotspot PDGFRB Mutations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2023

Dermawan Josephine K, Chiang Sarah, Hensley Martee L, Tap William D, Antonescu Cristina R

Abstract excerpt

PDGFRB-activating mutations have been reported in pediatric myofibroma and myofibromatosis. However, recurrent gain-of-function PDGFRB mutations have not been documented in sarcomas with myogenic differentiation. Driven by occasional sarcomas harboring PDGFRB mutations, we investigated their prevalence and clinicopathologic and genomic features in a large cohort of sarcomas. An institutional targeted DNA...

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Identifiers

PMID: 36788091
DOI: 10.1016/j.modpat.2023.100104
PMCID: PMC10198815

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