Article
TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibition.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2022
Chiang Sarah, Vasudevaraja Varshini, Serrano Jonathan, Stewart Colin J R, Oliva Esther, Momeni-Boroujeni Amir, Jungbluth Achim A, Da Cruz Paula Arnaud, da Silva Edaise M, Weigelt Britta, Park Kay J, Soslow Robert A, Murali Rajmohan, Ellenson Lora H, Benayed Ryma, Ladanyi Marc, Abu-Rustum Nadeem R, Dickson Mark A, Cohen Seth, Aghajanian Carol, Hensley Martee L, Lee Cheng-Han, Snuderl Matija, Konner Jason A
Abstract excerpt
Uterine perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm that occasionally shares morphologic and immunohistochemical overlap with low- and high-grade endometrial stromal sarcoma (LGESS and HGESS). In this study, we sought to characterize the clinical, morphologic, genetic, and epigenetic features of five uterine sarcomas that display histologic features of LGESS, HGESS, and PEComa. All...
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