Genomic prediction using mCADD scores as prior information in a mouse population.

Abstract excerpt

Although standard genomic prediction (GP) models such as genomic best linear unbiased prediction (GBLUP) assume that single-nucleotide polymorphisms (SNPs) contribute equally to genetic variation, some SNPs may be more informative than others because they are more closely linked to causal variants. GP models could therefore be finetuned by incorporating biological annotations. Here, we used combined annotation...

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