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Genetically Determined Alterations in Inflammation and Infection-Associated Genes are Associated With Hydrocephalus in Patients of African Ancestry.

Neurosurgery - 1 Aug 2026

Hale Andrew T, He Jing, Larkin Gregory M, Bastarache Lisa, Isaacs Albert M

Abstract excerpt

BACKGROUND AND OBJECTIVES: The genetic mechanisms underlying hydrocephalus (HC) risk and pathogenesis are diverse and complex. Although many human genetics studies of HC have been performed in European ancestry cohorts, the extent to which these genetic mechanisms are conserved in African ancestral populations is not known. In this study, we apply integrative human genetics and functional genomics approaches to...

Topics

Child
Child, Preschool
Female
Humans
Infant
Male
African People
Black or African American
Genetic Predisposition to Disease
Genome-Wide Association Study
Hydrocephalus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation

Membrane Proteins

Transcriptome

Source

Identifiers

PMID: 41222240
DOI: 10.1227/neu.0000000000003861

Genes

TMEM208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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