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Article

Modified heated dynamics and deep mutational scanning enhance anti-CXCR2 antibody affinity.

Journal of biomolecular structure & dynamics - 1 Aug 2026

Che Nordin Muhamad Alif, Choong Yee Siew, Che Omar Mohammad Tasyriq

Abstract excerpt

Colorectal cancer (CRC) is a leading global malignancy, with many stage IV cases requiring surgery and chemotherapy. However, chemoresistance limits treatment efficacy. Targeting resistance pathways such as CXCR2 with therapeutic antibodies offers a promising solution. This study harnessed deep mutational scanning guided by modified heated coarse-grained molecular dynamics (CGMD) simulations, to enhance the...

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Share to Antibody Affinity
Share to CXCR2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-8B

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Identifiers

PMID: 41217078
DOI: 10.1080/07391102.2025.2584341

Genes

CXCR2
C7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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