Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An integrated multiscale computational framework deciphers SARS-CoV-2 resistance to sotrovimab.

Biophysical journal - 20 Jan 2026

Sharma Akshit, Maurya Shweata, Kumar Shivank, Tripathi Timir, Kar Rajiv K, Padhi Aditya K

Abstract excerpt

The emergence of resistance mutations in the SARS-CoV-2 spike (S) protein presents a challenge for monoclonal antibody treatments like sotrovimab. Understanding the structural, dynamic, and molecular features of these mutations is essential for therapeutic advancements. However, the intricate landscape of potential mutations and critical residues conferring resistance to mAbs like sotrovimab remains elusive. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to COVID-19 Drug Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Machine Learning

Share to Molecular Dynamics Simulation

Share to Mutation

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 40394898
DOI: 10.1016/j.bpj.2025.05.015
PMCID: PMC12968846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An integrated multiscale computational framework deciphers SARS-CoV-2 resistance to sotrovimab.PMID 40394898Read ↗

Glycan shielding and epitope reorganization drive sotrovimab resistance in SARS-CoV-2 Omicron variants.Semantic proximity Read ↗

Bebtelovimab-bound SARS-CoV-2 RBD mutants: resistance profiling and validation with escape mutations, clinical results, and viral genome sequences.Semantic proximity Read ↗

Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune EscapeSemantic proximity Read ↗

Impact of BA.1, BA.2, and BA.4/BA.5 Omicron mutations on therapeutic monoclonal antibodies.Semantic proximity Read ↗

SARS-CoV-2 variants and bebtelovimab: immune escape mechanisms revealed by computational studies.Semantic proximity Read ↗

Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapiesSemantic proximity Read ↗

Mechanisms of Binding and Immune Escape Resistance for Broadly Neutralizing Antibodies Targeting Distinct Conserved SARS-CoV-2 Spike Epitopes: A Hierarchical Approach Integrating Mutational Profiling and Energy Landscape Analysis.Semantic proximity Read ↗

Dynamic mutational profiling of binding interactions and allosteric networks in conformational ensembles of the SARS-CoV-2 spike protein complexes with classes of antibodies targeting cryptic binding sites: confluence of binding and allostery determines molecular mechanisms and hotspots of immune escapeSemantic proximity Read ↗

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variantsSemantic proximity Read ↗

Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen designSemantic proximity Read ↗

The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV‑2 Spike ProteinSemantic proximity Read ↗

Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.