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Article

Machine learning-assisted diagnosis classification of primary immune dysregulation using IDDA2.1 phenotype profiling.

The Journal of allergy and clinical immunology - 1 Feb 2026

Schwitzkowski Malte, Veeranki Sai Pavan Kumar, Seidel Benedikt N, Kindle Gerhard, Rusch Stephan, Kramer Diether, Seidel Markus G

Abstract excerpt

BACKGROUND: Immune dysregulation, including autoimmunity, autoinflammation, allergy, and malignancy predisposition, adds significant disease burden in primary immune disorders (PID) and inborn errors of immunity (IEIs). OBJECTIVE: We evaluated whether the 5-graded immune deficiency and dysregulation activity (IDDA2.1) score, encompassing 21 organ involvement and disease burden parameters, supports diagnosis...

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PMID: 41202990
DOI: 10.1016/j.jaci.2025.10.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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