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Article

Integrated single-cell, spatial, and bulk transcriptomics reveal a chromatin regulator-TME prognostic framework guiding precision therapy in cervical cancer.

Journal of translational medicine - 6 Nov 2025

Tian Xiong, Lin Rong, Bao Jiaqian, Pan Yixiao, Liu Jianbo, Zhou Hanxi, Qu Hangshuai, Hu Dali, Wang Na

Abstract excerpt

BACKGROUND: Chromatin regulators (CRs) play a critical role in tumorigenesis, drug response, and prognosis, with dysregulation of chromatin regulator genes (CRGs) potentially disrupting the tumor immune microenvironment (TME) and influencing immune responses in cervical cancer. However, the prognostic and therapeutic implications of integrating CRGs and TME parameters in cervical cancer remain poorly understood....

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Source

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Identifiers

PMID: 41199302
DOI: 10.1186/s12967-025-07085-y
PMCID: PMC12590707

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TSPYL2

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