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Article

Hypertrophic Cardiomyopathy: The Impact of Age at Diagnosis of the Proband on Genetic Yield, Clinical Presentation, Outcomes, and Yield of Family Screening.

Journal of the American Heart Association - 18 Nov 2025

Silajdzija Elvira, Vissing Christoffer Rasmus, Christensen Emma Basse, Mills Helen Lamiokor, Kock Thilde Olivia, Andersen Lars Juel, Snoer Martin, Thune Jens Jakob, Bartels Emil Daniel, Axelsson Raja Anna, Christensen Alex Hørby, Bundgaard Henning

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy is a complex disease with variable clinical presentation and familial impact. Age at diagnosis may influence phenotypic expression, but it is unclear if age also affects clinical outcomes, genetic findings, and yield of family screening. METHODS: This was a retrospective cohort study of families screened for hypertrophic cardiomyopathy in eastern Denmark (2006-2023)....

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Identifiers

PMID: 41195766
DOI: 10.1161/JAHA.125.043711
PMCID: PMC12887210

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