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Article

Diagnostic validity and clinical utility of genetic testing for hypertrophic cardiomyopathy: a systematic review and meta-analysis.

Open heart - 1 Apr 2022

Christian Susan, Cirino Allison, Hansen Brittany, Harris Stephanie, Murad Andrea M, Natoli Jaime L, Malinowski Jennifer, Kelly Melissa A

Abstract excerpt

OBJECTIVE: This study summarises the diagnostic validity and clinical utility of genetic testing for patients with hypertrophic cardiomyopathy (HCM) and their at-risk relatives. METHODS: A systematic search was performed in PubMed (MEDLINE), Embase, CINAHL and Cochrane Central Library databases from inception through 2 March 2020. Subgroup and sensitivity analyses were prespecified for individual sarcomere genes,...

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Identifiers

PMID: 35387861
DOI: 10.1136/openhrt-2021-001815
PMCID: PMC8987756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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