Article
Nonfamilial Hypertrophic Cardiomyopathy: Prevalence, Natural History, and Clinical Implications.
Circulation. Cardiovascular genetics - 1 Apr 2017
Ingles Jodie, Burns Charlotte, Bagnall Richard D, Lam Lien, Yeates Laura, Sarina Tanya, Puranik Rajesh, Briffa Tom, Atherton John J, Driscoll Tim, Semsarian Christopher
Abstract excerpt
BACKGROUND: Yield of causative variants in hypertrophic cardiomyopathy (HCM) is increased in some probands, suggesting different clinical subgroups of disease occur. We hypothesized that a negative family history and no sarcomere mutations represent a nonfamilial subgroup of HCM. We sought to determine the prevalence, natural history, and potential clinical implications of this nonfamilial subgroup of HCM....
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