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Article

The relationship between otitis media and gastroesophageal reflux disease: A 2-sample Mendelian randomization analysis.

Medicine - 17 Oct 2025

Wang Xinyu, Yan Changhong, Yan Haoyang

Abstract excerpt

Existing research suggests a potential link between gastroesophageal reflux disease (GERD) and Otitis media (OM). Nevertheless, the specifics of this correlation are not clearly defined. In order to explore the genetic link between GERD and OM, this study engaged a 2-sample Mendelian randomization methodology. Initial steps comprised careful selection of instrumental variables, namely the single-nucleotide...

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Topics

Gastroesophageal Reflux
Humans
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Otitis Media
Genetic Predisposition to Disease

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Identifiers

PMID: 41189200
DOI: 10.1097/MD.0000000000044848
PMCID: PMC12537196

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