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Article

Causal link between ankylosing spondylitis and thyroid dysfunction: A Mendelian randomization study.

Medicine - 17 Oct 2025

Ye Qingqing, Liu Lin, Liu Bing

Abstract excerpt

Ankylosing spondylitis (AS) and thyroid dysfunction are prevalent conditions, with observational studies suggesting a possible association. However, the causal relationship remains unclear. This study employed two-sample Mendelian randomization (MR) to evaluate the bidirectional causal association between AS and thyroid dysfunction using genetic summary data. The inverse variance weighted (IVW) method was the...

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Topics

Humans
Mendelian Randomization Analysis
Spondylitis, Ankylosing
Hyperthyroidism
Hypothyroidism
Polymorphism, Single Nucleotide

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Identifiers

PMID: 41189132
DOI: 10.1097/MD.0000000000044862
PMCID: PMC12537079

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