Article
Refining the Sox10Dom/+ mouse model: A new breeding strategy with relevance to Hirschsprung disease genetics.
Animal models and experimental medicine - 1 Oct 2025
Lan Chaoting, Chen Jiazhang, Huang Shenwei, Mu Yide, Wang Qiuhua, Zhong Xin, Tang Ning, Zhao Xinying, Lu Jieting, Wu Yuxin, Huang Lihua, Zeng Jixiao, Zhong Wei, Ouyang Yu, He Qiuming, Zhang Yan
Abstract excerpt
BACKGROUND: The traditional Sox10Dom/+ mouse breeding strategy is costly and time-consuming, so this study aims to optimize the breeding method and improve the scientific research efficiency. METHODS: We select the offspring from mating B6C3Fe Sox10Dom/+ male mice with C57BL/6J female mice, and name the progeny B6C3Fe-g. Further, conduct separate self-breeding for both the B6C3Fe and B6C3Fe-g strains, adhering to...
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