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Article

Genetic associations with placental and pregnancy proteins in maternal serum identify biomarkers for hypertension in pregnancy.

American journal of obstetrics and gynecology - 1 Mar 2026

Yan Qi, Zhang Yu, Blue Nathan R, Truong Buu, Guerrero Rafael F, Honigberg Michael C, Parry Samuel, McNeil Rebecca B, Simhan Hyagriv N, Chung Judith, Mercer Brian M, Grobman William A, Silver Robert, Greenland Philip, Saade George R, Reddy Uma M, Wapner Ronald J, Liu Nianjun, Haas David M

Abstract excerpt

BACKGROUND: Preeclampsia is a complex syndrome that accounts for considerable maternal and perinatal morbidity and mortality. Despite its prevalence, no effective disease-modifying therapies are available. Maternal serum placenta-derived proteins have been in longstanding use as markers of risk for aneuploidy and placental dysfunction, but whether they have a causal contribution to preeclampsia is unknown....

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Identifiers

PMID: 41183724
DOI: 10.1016/j.ajog.2025.10.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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