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Article

Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected cases.

Scientific reports - 21 Oct 2020

McElrath Thomas F, Cantonwine David E, Gray Kathryn J, Mirzakhani Hooman, Doss Robert C, Khaja Najmuddin, Khalid Malik, Page Gail, Brohman Brian, Zhang Zhen, Sarracino David, Rosenblatt Kevin P

Abstract excerpt

We hypothesize that first trimester circulating micro particle (CMP) proteins will define preeclampsia risk while identifying clusters of disease subtypes among cases. We performed a nested case-control analysis among women with and without preeclampsia. Cases diagnosed < 34 weeks' gestation were matched to controls. Plasma CMPs were isolated via size exclusion chromatography and analyzed using global proteome...

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Identifiers

PMID: 33087742
DOI: 10.1038/s41598-020-74078-w
PMCID: PMC7578826

Genes

C1RL
GP1BA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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