Linking Genetics to Behavior: From Glutamatergic Genetic Variation Via Amygdala Morphology and Fear Recognition to Youths' Callous-Unemotional Traits and Reactive-Proactive Aggression.

doi:10.1016/j.bpsc.2025.10.012

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Linking Genetics to Behavior: From Glutamatergic Genetic Variation Via Amygdala Morphology and Fear Recognition to Youths' Callous-Unemotional Traits and Reactive-Proactive Aggression.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 May 2026

Kleine Deters Renee, Ruisch I Hyun, Naaijen Jilly, Aggensteiner Pascal-Maurice, Banaschewski Tobias, Schulze Ulrike M E, Craig Michael C, Sethi Arjun, Castro-Fornieles Josefina, Flamarique Itziar, Penzol María José, Brandeis Daniel, Werhahn Julia E, Glennon Jeffrey C, Buitelaar Jan K, Hoekstra Pieter J, Dietrich Andrea

Abstract excerpt

BACKGROUND: Although glutamatergic genetic variation, reduced amygdala volume, and impaired fear recognition have been linked to callous-unemotional (CU) traits and aggression, the pathways connecting these constructs remain unclear. Therefore, we examined associations between genetic proxies for glutamine/glutamate blood levels and CU traits; reactive and proactive aggression; and the mediating role of amygdala...

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PMID: 41173193
DOI: 10.1016/j.bpsc.2025.10.012

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