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Article

Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2020

Ruisch I Hyun, Dietrich Andrea, Klein Marieke, Faraone Stephen V, Oosterlaan Jaap, Buitelaar Jan K, Hoekstra Pieter J

Abstract excerpt

Aggression and callous, uncaring, and unemotional (CU) traits are clinically related behavioral constructs caused by genetic and environmental factors. We performed polygenic risk score (PRS) analyses to investigate shared genetic etiology between aggression and these three CU-traits. Furthermore, we studied interactions of PRS with smoking during pregnancy and childhood life events in relation to CU-traits....

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Identifiers

PMID: 31918432
DOI: 10.1038/s41386-020-0608-0
PMCID: PMC7075955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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