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Article

Inherited Genetic Risk of Liver Fibrosis in Lean Versus Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Alimentary pharmacology & therapeutics - 1 Mar 2026

Tesfai Kaleb, Díaz Luis Antonio, Arab Juan Pablo, Arrese Marco, Idalsoaga Francisco, Ayares Gustavo, Agrawal Saaket, Barreyro Fernando Javier, Gadano Adrian, Marciano Sebastián, Morales Jorge Martínez, Villela-Nogueira Cristiane, Leite Nathalie, Salles Gil, Cardoso Claudia Regina, Couto Claudia Alves, Theodoro Rafael, de Sousa Dias Monteiro Mísia Joyner, Oliveira Claudia P, Pessoa Mario G, Alvares-da-Silva Mario Reis, Huang Daniel Q, Madamba Egbert, Singh Seema, Lokanadham Snigdha, Bettencourt Ricki, Richards Lisa M, Khera Amit V, Loomba Rohit, Ajmera Veeral

Abstract excerpt

INTRODUCTION: Previous studies have revealed conflicting results regarding liver fibrosis risk in lean metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to compare the risk of significant fibrosis in lean versus nonlean MASLD and identify fibrosis-associated factors in lean MASLD. METHODS: The study was a cross-sectional analysis of prospectively enrolled adults with MASLD. Individuals...

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Identifiers

PMID: 41147688
DOI: 10.1111/apt.70433
PMCID: PMC12671836

Genes

HSD17B13
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Inherited Genetic Risk of Liver Fibrosis in Lean Versus Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).PMID 41147688Read ↗

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