Article
On-off-on electrochemiluminescence biosensor with dual-cycle amplification for ultrasensitive prenatal detection of thalassemia mutations using lanthanide europium nanorods.
Analytica chimica acta - 8 Dec 2025
Xie Ya-Qian, Wei Ya-Shu, Du Hang, Zhou Yu-Yi, Liu Lin-Yi, Wei Fu-Cun, Luo Yan-Ni, Tan Xue-Cai, Huang Ke-Jing, Feng De-Fen
Abstract excerpt
Herein, we develop an on-off-on electrochemiluminescence (ECL) biosensor with dual-cycle amplification for ultrasensitive prenatal detection of thalassemia mutations. The biosensor utilizes hydrothermally synthesized lanthanide europium nanorods (EuBTC), which possess abundant active sites and exhibit a 3.2-fold improvement in electron transfer efficiency compared to conventional spherical MOFs. By integrating...
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