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Article

JAK2 Unmutated Erythrocytosis: 2026 Update on Diagnosis and Management.

American journal of hematology - 1 Dec 2025

Gangat Naseema, Szuber Natasha, Tefferi Ayalew

Abstract excerpt

DISEASE OVERVIEW: JAK2 unmutated erythrocytosis encompasses a heterogeneous spectrum of hereditary and acquired entities. DIAGNOSIS: The foremost step is excluding polycythemia vera (PV) with JAK2 mutation screening (exons 12-15). Apparent polycythemia such as physiological outliers or relative polycythemia secondary to volume contraction should be considered. A historical overview of hematocrit (Hct) and...

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Source

Identifiers

PMID: 41123216
DOI: 10.1002/ajh.70118

Genes

JAK2
EPO
EPOR
PIEZO1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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