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Article

Polycythemia vera.

Mayo Clinic proceedings - 1 May 2026

Ellis Martin H, Barbui Tiziano, Tefferi Ayalew

Abstract excerpt

Polycythemia vera (PV) is a Philadelphia chromosome-negative myeloproliferative neoplasm arising from acquired JAK2 mutations (V617F or exon 12), resulting in constitutive activation of the JAK-STAT pathway and panmyelosis. This comprehensive review of the disease is based on relevant publications retrieved from a PubMed search using the terms polycythemia vera and epidemiology or pathophysiology or molecular...

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Identifiers

PMID: 41902804
DOI: 10.1016/j.mayocp.2026.01.008

Genes

JAK2
JAK1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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