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Article

Germline or somatic mutations in genes encoding microRNAs as biomarkers predicting the risk of adult T-cell leukemia/lymphoma.

Journal of human genetics - 1 Mar 2026

Nakashima Shimon, Nakano Masataka, Fukami Tatsuki, Ishida Takashi, Ri Masaki, Ishitsuka Kenji, Eguchi Go, Maeda Yasuhiro, Yonekura Kentaro, Sasaki Hidenori, Iida Shinsuke, Ueda Ryuzo, Osabe Makoto, Tohkin Masahiro, Nakajima Miki

Abstract excerpt

Single nucleotide polymorphisms in microRNA genes (miRNA-SNPs) can alter miRNA maturation or target mRNA recognition, resulting in gain- or loss-of-function, and are associated with various diseases. This study aimed to identify miRNA-SNPs or somatic mutations in miRNA gens that could serve as biomarkers for the onset or progression of adult T-cell lymphoma-leukemia (ATLL), using next-generation sequencing (NGS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41111079
DOI: 10.1038/s10038-025-01417-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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