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Genomic driver underlies clonal shift of methicillin-resistant Staphylococcus aureus in the healthcare setting.

Emerging microbes & infections - 1 Dec 2025

Li Shuangshuang, Huang Weiyi, Lyu Huiying, Zhang Qi, Ye Zhiyi, Lyu Yan, Xu Kai, Chen Tianchi, Xi Wei, Chen Xiaoying, Wang Yanan, Li Min, He Lei

Abstract excerpt

The epidemiology of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) has shifted in recent decades, with a notable decline in the lineage ST239 and continued dominance of ST5. The evolutionary mechanisms underlying these contrasting trends remain unclear. We conducted a longitudinal analysis of 3,410 clinical HA-MRSA isolates collected between 2005 and 2020 to assess clonal prevalence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41094743
DOI: 10.1080/22221751.2025.2576582
PMCID: PMC12584841

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