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Article

Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection.

The Journal of experimental medicine - 6 Jan 2020

Yang Jing, Schleicher Tyler R, Dong Yuemei, Park Hyun Bong, Lan Jiangfeng, Cresswell Peter, Crawford Jason, Dimopoulos George, Fikrig Erol

Abstract excerpt

Plasmodium infection in Anopheles is influenced by mosquito-derived factors. We previously showed that a protein in saliva from infected Anopheles, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT), inhibits the ability of sporozoites to traverse cells and readily establish infection of the vertebrate host. To determine whether mosGILT influences Plasmodium within the mosquito, we generated...

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Identifiers

PMID: 31658986
DOI: 10.1084/jem.20190682
PMCID: PMC7037243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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