Peripheral CD4+CD25+FOXP3+Tregs Cell Distribution in Women With and Without a History of Recurrent Pregnancy Loss in Relation to ACE rs4646994 (I/D) Polymorphism.

Abstract excerpt

PROBLEM: Recurrent pregnancy loss (RPL) a reproductive concern affects 1%-5% of couples worldwide and 50% of the cases are idiopathic. Pregnancy, a dynamic state of inflammation is influenced by diverse physiological factors. A multifunctional angiotensin converting enzyme (ACE) has direct effect on inflammation, oxidative stress, and fibrinolytic balance through Angiotensin-II. By blocking the NF-κB1...

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