A Complex FGF14 (TTC)/(TGC) Repeat Expansion in Parkinson's Disease.

doi:10.1002/mds.70128

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Article

A Complex FGF14 (TTC)/(TGC) Repeat Expansion in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2026

Zheng Xiaosheng, Cen Zhidong, Chen Xinhui, Zhang Fan, Ying Chenxin, Jin Nan, Liu Peng, Chen Yilin, Wang Haotian, Li Jiaxiang, Trinh Joanne, Laß Joshua, Pellerin David, Danzi Matt C, Zuchner Stephan, Brais Bernard, Lim Shen-Yang, Tan Ai Huey, Ahmad-Annuar Azlina, Yang Dehao, Wang Lebo, Lin Zhiru, Xie Fei, Wang Bo, Wu Sheng, Ouyang Zhiyuan, Chan Piu, Hu Shen, Klein Christine, Zheng Hou-Feng, Wang Chaodong, Luo Wei

Abstract excerpt

BACKGROUND: Repeat expansions have been reported as genetic causes/risk factors of Parkinson's disease (PD). As a novel repeat expansion locus, the FGF14-SCA27B (GAA)•(TTC) repeat locus is unexplored in PD. METHODS: Utilizing genetic sequencing and various polymerase chain reaction (PCR) methodologies, pure and complex repeat expansions in FGF14 were detected in Asian PD patients. Targeted long-read sequencing...

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Identifiers

PMID: 41277530
DOI: 10.1002/mds.70128

Genes

FGF14
GAA

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