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Feasibility of a ctDNA multigenic panel for non-small-cell lung cancer early detection and disease surveillance.

Molecular oncology - 1 Mar 2026

Casagrande Giovanna Maria Stanfoca, de Oliveira Silva Marcela, Dos Reis Mariana Bisarro, de Oliveira Cavagna Rodrigo, Sussuchi Luciane, Alves Pinto Icaro, Pontes Natalia Zampieri, Chiarantano Rodrigo Sampaio, da Silva Flavio Augusto Ferreira, de Marchi Pedro, Leal Letícia Ferro, Reis Rui M

Abstract excerpt

The detection of actionable mutations in liquid biopsies is a crucial tool for precision oncology in patients with non-small-cell lung cancer (NSCLC). We evaluated actionable alterations using a multigene panel in circulating tumor DNA (ctDNA) from Brazilian NSCLC patients. We analyzed 32 samples from 30 patients with NSCLC, including four samples from a lung cancer screening program. ctDNA isolation and library...

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Identifiers

PMID: 41071680
DOI: 10.1002/1878-0261.70131
PMCID: PMC13042580

Genes

EGFR
TP53
ALK
BRAF
KRAS
MAP2K1
MET
NRAS
PIK3CA
ROS1

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