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In Silico Deciphering of the Potential Impact of Variants of Uncertain Significance in Hereditary Colorectal Cancer Syndromes.

Cells - 6 Aug 2024

Fasano Candida, Lepore Signorile Martina, De Marco Katia, Forte Giovanna, Disciglio Vittoria, Sanese Paola, Grossi Valentina, Simone Cristiano

Abstract excerpt

Colorectal cancer (CRC) ranks third in terms of cancer incidence worldwide and is responsible for 8% of all deaths globally. Approximately 10% of CRC cases are caused by inherited pathogenic mutations in driver genes involved in pathways that are crucial for CRC tumorigenesis and progression. These hereditary mutations significantly increase the risk of initial benign polyps or adenomas developing into cancer. In...

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PMID: 39195204
DOI: 10.3390/cells13161314
PMCID: PMC11352798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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