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Article

Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation.

Journal of bacteriology - 20 Nov 2025

Varner Elizabeth, Meyer Mitchell, Whalen Jocelyn, Wang Yu-Hao, Rodriguez Carlos, Malik Ifra, Mullet Steven J, Gelhaus Stacy L, DePas William H

Abstract excerpt

Nontuberculous mycobacteria (NTM) can form biofilms during human infection and in household plumbing systems, so understanding biofilm regulation could help us better treat and prevent NTM infections. Glucose drives NTM aggregation in vitro, and ammonium inhibits it, but the regulatory systems controlling this early step in biofilm formation are not understood. Here, in the model NTM Mycobacterium smegmatis, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41060069
DOI: 10.1128/jb.00252-25
PMCID: PMC12632254

Genes

NTM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation.PMID 41060069Read ↗

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