Article
Defining a temporal order of genetic requirements for development of mycobacterial biofilms.
Molecular microbiology - 1 Sept 2017
Yang Yong, Thomas Joseph, Li Yunlong, Vilchèze Catherine, Derbyshire Keith M, Jacobs William R, Ojha Anil K
Abstract excerpt
Most mycobacterial species spontaneously form biofilms, inducing unique growth physiologies and reducing drug sensitivity. Biofilm growth progresses through three genetically programmed stages: substratum attachment, intercellular aggregation and architecture maturation. Growth of Mycobacterium smegmatis biofilms requires multiple factors including a chaperonin (GroEL1) and a nucleoid-associated protein (Lsr2),...
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