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Article

Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis.

Virchows Archiv : an international journal of pathology - 1 Jun 2026

Amer Faizan, Hassan Usman, Mushtaq Sajid, Loya Asif, Hussain Mudassar, Maqbool Hina

Abstract excerpt

Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad...

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PMID: 41057664
DOI: 10.1007/s00428-025-04280-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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