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Article

Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936.

Molecular psychiatry - 1 Jan 2026

Deary Ian J, Harris Sarah E, Russ Tom C, Cox Simon R, Corley Janie

Abstract excerpt

Variation in the gene for apolipoprotein E (APOE) is one of the few variables that is associated with individual differences in age-related cognitive decline in humans. Therefore, it is important to understand the conditions that affect the strength of its effect. Here we examine how the effect size of APOE variation (possession of one or more e4 alleles) on a test of general cognitive ability changes with age...

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Identifiers

PMID: 41053433
DOI: 10.1038/s41380-025-03274-9
PMCID: PMC12700797

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936.PMID 41053433Read ↗

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